Acute lymphoblastic leukemia
Conditions
Interventions
Experimental group:CHALL-2020
control group:CHALL-2013
Sponsors
Changhai Hospital, Naval Medical University, PLA
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All of the following conditions must be met: 1.The initial diagnosis of acute lymphoblastic leukemia was confirmed by bone marrow MICM examination; 2. Aged between 16 and 60 years old; 3. The ECOG physical status score is 0-2 points; 4. No history of malignant tumor; no other tumors occurred at the same time; 5. The investigator judges patients whose life expectancy is at least 6 months; 6. Volunteer to participate in this experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: It shall be excluded as long as one of the following is satisfied: 1. Mature B-ALL, mixed phenotype leukemia (excluding ALL with myeloid antigen expression); 2. Patients with second tumor, clear CML sudden change; 3. Patients who used glucocorticoids for more than 7 days from 1 month to 1 week before enrollment, or had any history of chemotherapy or radiotherapy in the first 3 months (emergency radiotherapy taken to relieve oppressive symptoms is not excluded); 4. LVEF=50%; 5. Those who suffer from other uncontrolled diseases that the researcher thinks are not suitable for joining; 6. Psychiatric patients or other patients who are known or suspected to be unable to fully comply with the research protocol; 7. Pregnant or lactating women; 8. People infected with HIV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EFS;OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| relapse CIN;treatment-related mortality;whole transcriptome sequencing;CSF Metabolomics; | — |
Countries
China
Contacts
Public ContactJianmin Yang
Changhai Hospital, Naval Medical University, PLA
Outcome results
None listed