sarcoidosis, tuberculosis
Conditions
Interventions
Gold Standard:Biopsy pathological specimen, and sputum AFB smear
Index test:XpertMTB/RIF Ultra
Sponsors
Shanghai Pulmonary Hospital Tongji University, School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Male or female, aged 18 to 80 years old; 2. Patients with mediastinal or / and hilar lymphadenopathy found by chest CT 3.suspected intrathoracic granulomatous lymphadenopathies diagnosed by two physicians specialized in pulmonary diseases based on patient clinical and radiological (examined by two radiologists) 4.negative sputum AFB smear (at least for three times before the bronchoscopy); 5.No evidence of tumor was found in sputum and other body fluids before biopsy; 6.Patients must be able to fully understand the informed consent form, agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients who have been anti tuberculosis therapy in the past; 2.Patients who have been confirmed with malignancy by lung puncture and other means; 3.Patients who was suspected with tumor by clinical and imaging; 4.Patients who was considered with infection other than tuberculosis; 5.The patients who were judged by the physician in charge of the trial or the physician in charge of the trial as not suitable for this trial; 6.Patients who are not suitable for obtaining pathological tissue specimens.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| positive;negative;SPE, SEN, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactQiuhong Li
Shanghai Pulmonary Hospital Tongji University, School of Medicine
Outcome results
None listed