Severe acute pancreatitis
Conditions
Interventions
hemofiltration:short-term hemofiltration
Control group:Conventional treatment
Sponsors
The First Affiliated Hospital of Naval Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old; 2. Onset time <48h; 3. Acute persistent abdominal pain, with or without radiating pain; blood amylase is more than 3 times higher than the normal threshold; 4. Imaging findings such as abdominal ultrasound, enhanced CT or MRI showed signs of acute pancreatitis, accompanied by organ failure. According to the Atlanta classification criteria, the diagnosis was MSAP/SAP; 5. Agree to participate in this clinical study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Mild acute pancreatitis; 2. Pancreatitis of pregnancy; 3. MSAP/SAP has undergone surgical debridement and drainage, NOTES, ERCP and other interventional or surgical treatments; 4. Acute renal failure (diagnostic criteria: serum creatinine rise >=26.5umol/L (0.3mg/dL) within 48 hours; or serum creatinine rise to >=1.5 times the baseline value within 7 days; or urine output for 6 hours <0.5ml /Kg/h); 5. Complicated with diseases such as active bleeding, malignant tumor, hepatitis, chronic liver failure or chronic renal failure; 6. Pregnant women, patients with mental illness; 7. The researcher believes that there are any other factors that are not suitable for selection or that affect the participants' participation in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SIRS duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effective treatment rate;Mortality;Total hospital days;Hospital charge; | — |
Countries
China
Contacts
Public ContactDu Yiqi
Changhai Hospital
Outcome results
None listed