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Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in Gastric Cancer

Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in Gastric Cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000036031
Enrollment
Unknown
Registered
2020-08-21
Start date
2021-01-01
Completion date
Unknown
Last updated
2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric cancer

Interventions

Case series:Nil

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) Male of female, aged 18 to 75 years; 2) ECOG 0,1 or 2; 3) Pathologically confirmed adenocarcinoma (including Lauren type); 4) Initial resectable, cT3/4N+M0; 5) No previous tumor treatment including chemotherapy, radiotherapy, et al.; 6) No other malignant tumor or history of malignant tumor within five years; 7) Informed consent.

Exclusion criteria

Exclusion criteria: 1) Verified tumor unresectable or distant metastasis during operation; 2) No qualified blood samples were collected in pre- or post-operative period; 3) No blood matched tissue samples; 4) No complete clinical information and follow-ups; 5) Any systemic disease contrary to this study.

Design outcomes

Primary

MeasureTime frame
cfDNA CNVs;—

Countries

China

Contacts

Public ContactTang Zhaoqing

Zhongshan Hospital, Fudan University

tang.zhaoqing@zs-hospital.sh.cn+86 13817125778

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026