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Evaluation and clinical application of skin green autofluorescence as a diagnosis biomarker for early lung cancer

Evaluation and clinical application of skin green autofluorescence as a diagnosis biomarker for early lung cancer

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000036026
Enrollment
Unknown
Registered
2020-08-21
Start date
2020-10-01
Completion date
Unknown
Last updated
2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Gold Standard:pathology
autofluorescence&#32

Sponsors

Shanghai Chest Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: The first stage: (1) Aged 18-75 years old; (2) in patients with nodules found in the lungs by low-dose or ordinary CT examination, the nodules are 5 mm-3 cm in size, and there is only one nodule per patient in this range, and other nodules less than or equal to 5 mm are allowed to exist at the same time; (3) the nodules were confirmed as benign or malignant by tracheoscopy, puncture biopsy or operation and pathology; (4) the CT of the patient must be a high-resolution three-bit reconstruction image of Shanghai Thoracic Hospital. The second stage: Part one: (1) over 18 years of age; (2) in patients with nodules found in the lungs by low-dose or ordinary CT examination, the nodules are 5 mm-3 cm in size, and there is only one nodule per patient in this range, and other nodules less than or equal to 5 mm are allowed to exist at the same time; (3) the CT of the patient must be a high-resolution three-bit reconstruction image of Shanghai Thoracic Hospital. The second part: (1) Aged 18-75 years old; (2) patients with non-small cell lung cancer confirmed by pathology. The third part: (1) Aged 18-75 years old; (2) patients with advanced non-small cell lung cancer confirmed by pathology.

Exclusion criteria

Exclusion criteria: The first stage: (1) patients with a history of stroke, pneumonia, COPD and pulmonary hypertension. (2) patients with hypertension and hyperglycemia are not well controlled. (3) patients with suspected multicentric ground glass nodules. (4) patients who can not cooperate with skin fluorescence detection. The second stage: Part one: (1) patients with a history of stroke, pneumonia, COPD and pulmonary hypertension. (2) patients with hypertension and hyperglycemia are not well controlled. (3) patients with suspected multicentric ground glass nodules. (4) patients who can not cooperate with skin fluorescence detection. The second part: (1) patients with a history of stroke, pneumonia, COPD and pulmonary hypertension. (2) patients with hypertension and hyperglycemia are not well controlled. (3) patients who can not cooperate with skin fluorescence detection. The third part: (1) patients with a history of stroke, pneumonia, COPD and pulmonary hypertension. (2) patients with hypertension and hyperglycemia are not well controlled. (3) patients who can not cooperate with skin fluorescence detection.

Design outcomes

Primary

MeasureTime frame
Skin green autofluorescence;SEN, SPE, ACC, AUC of ROC;

Countries

China

Contacts

Public ContactTianqing Chu

Shanghai Chest Hospital

tianqing_chu@126.com+86 13661775640

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026