Haemolytic anaemia
Conditions
Interventions
Gold Standard:1. Hereditary spherocytosis: peripheral blood red blood cell morphology test, red blood cell osmotic fragility test
2. Glucose-6-phosphate dehydrogenase deficiency anemia: erythrocyte G-6-PD activity assay, genetic analysis
3. Thalassemia: hemoglobin electrophoresis, genetic analysis
4. Autoimmune hemolytic anemia: anti-human globulin test.
Index test:Reticulocyte 
parameters:mean 
spherical 
blood 
cell 
reticulocyte 
volume.
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 90 Years
Inclusion criteria
Inclusion criteria: Diagnostic criteria of typical hemolytic anemia: 1. Hereditary spherocytosis: erythrocytosis in peripheral blood, increased osmotic fragility of red blood cells; 2. Glucose-6-phosphate dehydrogenase deficiency anemia: decreased red blood cell G-6-PD activity or genetic analysis; 3. Thalassemia:hemoglobin electrophoresis or genetic analysis; 4. Autoimmune hemolytic anemia:positive for anti-human globulin test.
Exclusion criteria
Exclusion criteria: 1. The patient or family refused to participate in the study; 2. Incomplete clinical data, lack of closely related test items; 3. Including the blood transfusion treatment within the first 3 months; 4. Patients have tumors and serious infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reticulocyte parameters;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactLin Faquan
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed