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Evaluation of IL10 and TGF-beta levels in blood as a biomarker of peri-prosthetic joint infection

Evaluation of IL10 and TGF-beta levels in blood as a biomarker of peri-prosthetic joint infection

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000035969
Enrollment
Unknown
Registered
2020-08-20
Start date
2018-10-02
Completion date
Unknown
Last updated
2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periprosthetic joint infection

Interventions

Gold Standard:Preoperative CRP, ESR, WBC, complete blood count (CBC) parameters, urinalysis, total protein, and albumin values of patients
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Sponsors

namik kemal health application & research center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
54 Years to 80 Years

Inclusion criteria

Inclusion criteria: A healthy control group and patients who underwent primary total arthroplasty surgery between October 2018 and November 2019, and who were hospitalized and treated with the diagnosis of chronic PJI was included in this study. The diagnosis of PJI in patients was determined according to the criteria determined by the MSIS and modified by the ICM

Exclusion criteria

Exclusion criteria: Patients with chronic disease or acute infection findings that might affect cytokine levels were excluded from the study. The primary arthroplasty surgery of the patients in group 2 and group 4 was performed in our clinic. Patients with a previous history of additional surgical intervention of the knee or hip, patients who had undergone unicondylar knee or partial hip replacement, patients aged over 80 years, and patients with outpatient follow-up less than 6 months were not included in the study. Patients with additional diseases that might predispose to infection and therefore PJI, other than hypertension, were excluded from the study.

Design outcomes

Primary

MeasureTime frame
comparison TGF-B and IL-10 levels and other serum infection markers;

Countries

Türkiye

Contacts

Public Contactburak günaydin

Namik Kemal University Health and Application Center

docburak@gmail.com+905557887965

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026