Recurrent spontaneous abortion due to atypical antiphospholipid antibody positive syndrome
Conditions
Interventions
Control group:Daphone: 10mg, Q8h, oral
Hydroxychloroquine group 1: hydroxychloroquine 200mg/ day + Dafotone orally
Hydroxychloroquine group 2:hydroxychloroquine 200mg/ day + Daphne + aspirin (50mg/ day) orally
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1) Married women aged 20 to 35 years; 2) Meet ACA positive atypical APS diagnostic criteria.
Exclusion criteria
Exclusion criteria: 1) Progesterone <20ng/ml; 2) Positive anti-lupus anticoagulant (LA); 3) Those who do not meet the diagnostic criteria for this disease; 4) Patients with reproductive system tumors and malformations; 5) Patients with severe diseases such as heart, brain, liver and kidney and abnormal mental state; 6) Chromosomal abnormalities and blood type incompatibility between the husband and wife; 7) Abnormal endocrine function; 8) The eugenics and eugenics test suggested cytomegalovirus, Toxoplasma virus, rubella virus and herpes simplex virus infection; 9) Abnormal blocking antibody; 10) Abnormal semen of the husband; 11) Those who have recently used similar drugs for treatment, or taken drugs with related or antagonistic effects, resulting in the difficulty in determining the efficacy of drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ACA and related antibodies;Indicators of coagulation function;Pregnancy-related hormone indicators;Fetal growth and development related indicators; | — |
Countries
China
Contacts
Public ContactYinyan He
Shanghai General Hospital
Outcome results
None listed