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Study on precise classification of diagnosis and treatment of hyperinsulinemic hypoglycemia in children

Study on precise classification of diagnosis and treatment of hyperinsulinemic hypoglycemia in children based on PET/CT and full exon sequencing precision typing

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000035943
Enrollment
Unknown
Registered
2020-08-20
Start date
2021-01-01
Completion date
Unknown
Last updated
2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hyperinsulinemic hypoglycemia

Interventions

Case series:Nil

Sponsors

Children's Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Abnormally elevated serum insulin or C-peptide can be detected when blood glucose is lower than 2.6mmol/ L; (2) To maintain blood glucose above 3mmol/L, continuous glucose infusion is required and the glucose rate should be maintained above 8mg/kg/min; (3) Non-ketotic hypoglycemia, i.e., low serum ketone body level, low serum free fatty acid level or no detection during hypoglycemia; (4) It responded to hypodermic or intramuscular injection of glucagon, and the increase of blood glucose was greater than 2mmol/L.

Exclusion criteria

Exclusion criteria: (1) Ketosis hypoglycemia; (2) Neonatal temporary hypoglycemia; (3) Hypoglycemia secondary to other energy metabolism disorders; (4) Exclude hypoglycemia secondary to other related genetic metabolic diseases.

Design outcomes

Primary

MeasureTime frame
blood glucose;—

Countries

China

Contacts

Public ContactZhang Miaoying

Children's Hospital of Fudan University

miaoyingzhang@126.com+86 13671793450

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026