cholangiocarcinoma
Conditions
Interventions
GB:gemcitabine+bortezomib
control:GP/GEMOX
Sponsors
Oriental Hepatobiliary Surgery Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Pathological or cytological diagnosis of cholangiocarcinoma; 2. Measurable evaluation according to RECIST standard; 3. Aged 18 to 75 years; 4. WHO/ECOG physical strength score is 0-2; 5. Evaluation as progress according to RECIST criteria; 6. Blood routine examination: white blood cell > 3.0 x10^9/L, platelet > 100 x10^9/L; 7. Adequate liver reserve (bilirubin 60 ml/min; Creatinine < 120 mol/L); 9. Centerless dysfunction, chest pain (not medically controllable).No myocardial infarction occurred within 12 months prior to study initiation; 10. signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Secondary malignant tumor or other tumor accompanied within 3 years prior to the start of the study; 2. There is a brain or meningeal metastasis; 3. Contraindication of bortezomib; 4. Chronic diarrhea or colorectal inflammatory conditions, or untreated obstructions or subobstructions affecting systemic administration; 5. Active infections or other severe infections that may prevent the patient from receiving the planned treatment.For example, chronic, uncontrolled cholangitis that destroys branches of the biliary tract and cholangitis that has occurred twice or more in the past six months.Other active or uncontrolled infections, cirrhosis, or chronic active hepatitis should also be excluded; 6. Cardiac insufficiency, unstable angina pectoris, congestive heart failure, failure myocardial infarction and severe uncontrolled arrhythmia within 6 months before enrollment; 7. Participated in other clinical trials for research; 8. Pregnant and lactating women; 9. Individuals undergoing calibration monitoring or monitoring.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| survival time; | — |
Countries
China
Contacts
Public ContactHongyang Wang
Oriental Hepatobiliary Surgery Hospital
Outcome results
None listed