acute respiratory failure
Conditions
Interventions
Group 1:Prone Positioning in patients with HFNC
Group 2:HFNC
Sponsors
Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old, male or female; 2. Meet the diagnostic criteria of ARF (ARDS), and the diagnosis of ARF shall not exceed 48 hours until the enrollment: 1) The disease occurs within one week after the known cause or the onset of new or aggravating respiratory symptoms; 2) Reduced transmittance of both lungs, and could not be completely explained by pleural effusion, atelectasis or tuberosity; 3) Respiratory failure that cannot be explained by cardiac failure or fluid overload, and if there are no risk factors, an objective assessment (e.g., cardiac ultrasonography) is required to exclude pulmonary edema due to increased hydrostatic pressure; 4) PaO2/FiO2=5 cmH2O; 3. Admitted to the intensive care unit or equipped with bedside respiratory circulation monitoring facilities; 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Respiratory muscle fatigue (RR > 40/min and PaCO2 > 60mmHg/pH =0.5 ug/kg*min); 3. Decreased level of consciousness, Glasgow coma Scale (GCS) 35 kg/m^2; 7. Contraindications to prone position: 1) Open thoracic and abdominal wounds and large wounds; 2) Abdominal surgery within 4 days; 3) Intra-abdominal high pressure; 4) Facial, pelvic and spinal fractures or instability; 5) Chest trauma, untreated pneumothorax; 6) Skeletal deformities affecting prone position, such as severe posterior scoliosis and severe limb contracture; 7) Fatal arrhythmia. 8. Other conditions in the treatment group that immediate endotracheal intubation and invasive mechanical ventilation are required; 9. Pregnant or breast-feeding patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubation rate in 28 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality in 28 days; | — |
Countries
China
Contacts
Public ContactWang Ruilan
Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine
Outcome results
None listed