Artificial intelligence for pathological grading system of ganglion cells for intraoperative rapid biopsy in Hirschsprung disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000035860

Enrollment

Unknown

Registered

2020-08-18

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hirschsprung disease

Interventions

Gold Standard:The speciemens and sections will be reveiwed by three senior pediatric gastroenterology pathologists under the novel pathological grading system of ganglion cells in Hirschsprung disease

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system

Eligibility

Sex/Gender

All

Age

No minimum to 16 Years

Inclusion criteria

Inclusion criteria: 1. Patients with histopathologically confirmed Hirchsprung Disease, including short-segment HSCR, long-segment HSCR and total colon aganglionosis. 2. Complete clinical data and pathological information; 3. Patients who signed written informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1. The pathologic diagnosis is intestinal neuronl dysplasia; 2. The pathologic diagnosis is chronic intestinal pesudo-obstruction. 3. Combined with chromosomal abnormalities and other congenital disorders.

Design outcomes

Primary

Measure	Time frame
the area under the receiver operating characteristic (AUC);Accuracy;Sensitivity;Specificity;Positive predictive values;Negative predictive values;	—

Countries

China

Contacts

Public ContactZhang Minzhong

Xinhua Hospital, Shanghai Jiaotong University School of Medicine

zhangminzhong@outlook.com+86 18516057500

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026