colorectal cancer
Conditions
Interventions
experimental group 1:Lycium barbarum polysaccharides
Experimental group 2:probiotics
experimental group 3:probiotics+ Lycium barbarum polysaccharides
Control group:placebo
Sponsors
Shanghai Tenth people's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with newly diagnosed colorectal cancer; 2. They were able to obtain tumor resection tissue samples, fasting plasma samples and fecal samples before treatment at the same time; 3. aged 18-60 years old; 4. Expected length of stay >=7 days; 5. BMI at admission was 18.5 – 28.0 kg / m2 (inclusive); 6. Without history of other organ tumors and intestinal surgery; 7. Without history of Liver and kidney dysfunction; 8. No antibiotics were used in the past 6 months; 9. No chemotherapy or radiotherapy was given 2 weeks before admission.
Exclusion criteria
Exclusion criteria: 1. Chemotherapy or radiotherapy was given 2 weeks before admission; 2. The expected length of stay was less than 7 days; 3. Pregnant or lactating female patients; 4. The expected survival time was less than 30 days; 5. General condition is poor, severe malnutrition patients. 6. BMI 28.0 kg / m2 at admission; 7. Liver and kidney dysfunction (liver and kidney function index higher than the upper limit of normal value 20%); 8. Patients with familial adenomatous polyposis (FAP) or hereditary nonpolyposis colorectal cancer (HNPCC); 9. Patients with tumor recurrence, distant metastasis, unable to undergo radical resection, or complicated with other organs or multiple organ dysfunction; 10. Patients with inflammatory bowel disease (IBD), metabolic disease (such as diabetes, obesity) or infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short chain fatty acids;IL-1 beta;IL-6;IL-4;IL-10;Immune interferon;tumor necrosis factor;MUC-2;Bcl-xL;NF-kB;IkB alpha;CRP;SIgA;postoperative abdominal pain;Flora richness;Flora diversity;Flora structure; | — |
Secondary
| Measure | Time frame |
|---|---|
| TFF3;Occludin;ZO-1;p53;p21;Bax;Bcl-2;?-Catenin;the total number of normal leukocyte;the number of neutrophils;postoperative diarrhea;postoperative abdominal distention;postoperative complications; | — |
Countries
China
Contacts
Public ContactTing Han
Shanghai Tenth people's Hospital
Outcome results
None listed