Dentition defect
Conditions
Interventions
A:Biomimetic calcium phosphate bone
B:Calcium phosphate bone meal
Sponsors
The Ninth People's Hospital Affiliated to medical school of Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients over 18 years old; 2. Patients with single tooth extraction in accordance with the indications of tooth extraction; 3. The subjects who met the indications for site preservation (eds-1 and eds-2 grades according to n. caplanis et al. (2005)); 4. Patients choose to receive implant therapy; 5. The subjects voluntarily signed the informed consent form before carrying out any research related trial steps.
Exclusion criteria
Exclusion criteria: 1. Patients with uncontrolled local inflammation of extracted teeth and adjacent teeth, including uncontrolled periodontitis (periodontal probing depth > 4mm) and acute periapical periodontitis; 2. Patients with oral mucosal lesions (such as lichen planus, leukoplakia); 3. Patients with space occupying lesions (including cysts, tumors, etc.) in extracted teeth and adjacent teeth; 4. Patients with systemic diseases affecting bone healing, wound healing and dental implant treatment (if stable diabetes is not controlled, fasting blood glucose is still >= 8.8 mmol / L after drug control); 5. Patients with uncontrolled and stable severe hypertension (higher than 180 / 100 mmHg); 6. Contraindications of conventional implant surgery and oral surgery, including bone graft surgery; 7. Patients with heart disease (grade II and above cardiac function diseases); 8. Patients with liver and kidney dysfunction or abnormal; 9. In obese patients, BMI > 28 kg / m2; 10. Patients who have received full dose radiotherapy, local radiotherapy of head or neck; 11. Patients who need long-term high-dose steroid therapy; 12. Patients who have been treated with drugs (such as bisphosphonates) that may affect or promote bone metabolism and other patients with abnormal calcium and phosphorus metabolism in recent 3 months; 13. Patients who received antibiotic therapy or chronic anti-inflammatory therapy (more than 3 times a week) in the first 4 weeks before operation; 14. Patients with alcoholism or long-term drug abuse; 15. Patients with immune insufficiency; 16. Smoking / tobacco equivalent / chewing tobacco more than 10 cigarettes per day; 17. Physical or mental defects affect the objects of oral health care; 18. Patients allergic to products; 19. Pregnant or lactating women; 20. Patients with poor compliance who could not participate in the trial according to the researchers; 21. Within 30 days prior to the start of surgery (study day 0), patients participated in clinical trials of other drug devices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The volume density of the new bone in biopsy samples at the tooth extraction site 6 weeks after preservation;Volume density of residual bone filling material in biopsy samples at tooth extraction site 6 weeks after preservation;The contour width and height of the hard tissue changed 6 weeks after tooth extraction;Changes in soft tissue contour volume at 6 weeks after tooth extraction;Soft tissue healing score at 6 weeks after tooth extraction;The parameters of blood routine;Blood biochemistry;Coagulation function;Serum immunoglobulin;Serum bone morphogenetic protein 2;OHIP14; | — |
Countries
China
Contacts
Public ContactYu Dedong
The Ninth People's Hospital Affiliated to medical school of Shanghai Jiaotong University
Outcome results
None listed