Effect of nalmefene on recovery quality of patients undergoing general anesthesia
Conditions
Interventions
Experimental group:0.25ug/kg Nalmefene
Control group:1ml normal saline will be injected intravenously
Sponsors
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years old; 2. Elective general anesthesia for orthopedics, urology and thoracic surgery; 3. ASA class I or II; 4. BMI 18 to 30kg/ m2; 5. Anesthesia time was 2-4 hours, and anesthetic analgesics (sufentanil and remifentanil) were used during operation 6. The patient used electronic intravenous analgesia pump after operation; 7. Signed Informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous severe cerebrovascular accident and other nervous system diseases; 2. Mental illness, long-term use of drugs that affect the function of the central nervous system, benzodiazepines or opioids; 3. History of allergy to narcotic drugs; 4. History of drug addiction and alcoholism; 5. The patient was diagnosed with severe cardiopulmonary disease, or active heart disease, or abnormal liver function (AST and ALT were 1.5 times higher than the normal value), and renal insufficiency (serum creatinine and urea nitrogen were 1.2 times higher than the normal value); 6. Participate in other clinical trials within 4 weeks; 7. Abnormal cognition or communication determined by the researcher; 8. Emergency and critical condition occurred during the operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from the end of operation to Aldrete score >=9; | — |
Countries
China
Contacts
Public ContactLiu Jueying
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed