Cholangiocarcinoma
Conditions
Interventions
all:systemic therapy for unresectable advanced cholangiocarcinoma
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1. the patient voluntarily signs the informed consent form; 2. Aged >=18 years old; 3. histologically or cytologically confirmed advanced intra- or extra-hepatic cholangiocarcinoma which is unresectable 4. measurable leisons >=1 (based on RECIST 1.1); 5. the estimated survival time >=3 months; 6. Well compliance and to be able to follow-up; 7. the patient is with the desire of ctDNA test before and after therapy.
Exclusion criteria
Exclusion criteria: 1. pregnant or lactational woman; 2. the baseline hCG test was postive or female patient of reproductive age did not receive hCG test; 3. fertile patients who refused to contraception; 4. patient with attack of other malignancy in 5 years(exculde cured basal cell carcinoma and cervical carcinoma in situ); 5. patient with central nerve system disease; 6. recent cardiovascular disease, include cerebrovascular accient within 6 months, heart infraction with in 6 months, unstable angina, congestive heart failure grade II or above(NYHA classification),severe arrhythmia and uncontroled hypertension; 7. uncontroled severe infection; 8. severe liver or renal disfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate, ORR;Progression-Free-Survival, PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival, OS; | — |
Countries
China
Contacts
Public ContactWang Xuan
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Outcome results
None listed