critical ill infection
Conditions
Interventions
Routine antimicrobial regimen group:Meropenem dose was adjusted according to the glomerular filtration rate of patients
PPK model-guided antimicrobial regimen group: Meropenem dose was determined according to the PPK model
Sponsors
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients admitted to the Department of Critical Care Medicine, Ruijin Hospital affiliated to Shanghai Jiao Tong University who met the inclusion criteria were admitted to the clinical study after signing the informed consent. 2. Aged >=18 years old; 3. Meropenem was applied according to clinical requirements, the infusion frequency was Q8h, and the infusion method was continuous infusion (2.5h).
Exclusion criteria
Exclusion criteria: 1. Patients requiring renal replacement therapy and extracorporeal membrane oxygenation treatment; 2. Meropenem was used within one week; 3. End-stage renal disease, namely GFR 32 kg/m2; 5.ICU stay <4 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| meropenem target rate of PK/PD; | — |
Countries
China
Contacts
Public ContactHongping Qu
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed