recurrent nasopharyngeal carcinoma
Conditions
Interventions
Experimental group:Endoscopic nasopharyngectomy combined with postoperative gemcitabine and cisplatin chemotherapy
Control group:Endoscopic nasopharyngectomy
Sponsors
Affiliated Eye Ear Nose and Throat Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with NPC recurrence after radical radiotherapy were confirmed by pathology; 2. Patients with negative pathological margin after endoscopic skull base minimally invasive surgery 3. According to the TNM staging criteria of nasopharyngeal carcinoma (AJCC, 8th Edition, 2017), rT2, rT3, and rT4 patients who were assessed by the surgical team could undergo total resection. 4. If there was cervical lymph node metastasis, surgical resection and local control could be used.
Exclusion criteria
Exclusion criteria: 1. Patients with positive pathological margin after endoscopic skull base minimally invasive surgery; 2. Recurrent nasopharyngeal carcinoma with distant metastasis; 3. The patients who did not get the information of pathological margin during operation; 4. Patients with poor general condition and unable to tolerate treatment; 5. Patients with contraindications to chemotherapy were assessed by a multidisciplinary team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS;QOL; | — |
Secondary
| Measure | Time frame |
|---|---|
| LRFS;PFS;DMFS; | — |
Countries
China
Contacts
Public ContactDehui Wang
Affiliated Eye Ear Nose and Throat Hospital, Fudan University
Outcome results
None listed