Anesthesia
Conditions
Interventions
Remimazolam Tosilate:Injection Remimazolam
Diprivan:Injection Diprivan
Sponsors
Department of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Aged 65 to 85 years; (2) The American society of anesthesiologists (ASA) class I ~ II, or ASA class III that basic diseases in internal medicine were under stable control; (3) 18 kg/m2 < Body mass index (BMI) < 30kg /m2; BMI = weight/height squared in kg/m2.
Exclusion criteria
Exclusion criteria: (1) Patients requiring endotracheal intubation; (2) Difficult airway, acute respiratory infection and asthmatic attack stage; (3) Uncontrolled severe hypertension or hypotension (systolic blood pressure >=160 mmHg, diastolic blood pressure >=100 mmHg, systolic blood pressure <= 90 mmHg, diastolic blood pressure <= 60 mmHg, consistent with any one item), severe arrhythmia, and unstable angina; (4) Anemia, Hb < 80g/L; (5) A history of drug abuse and/or alcohol abuse within 2 years prior to the start of the screening period, i.e. an average of more than 2 units of alcohol per day (1 unit =360 mL beer or 45 mL white wine or 150 mL wine with a 40% alcohol content); (6) Acute upper gastrointestinal hemorrhage, acute gastrointestinal perforation, gastrointestinal obstruction accompanied by gastric content retention; (7) A history of mental illness or long-term use of psychotropic drugs or chronic analgesics; (8) Allergic to benzodiazepines, opioids, propofol, lidocaine and their drug components; (9) Patients had taken other test drugs or been involved in other clinical trials within three months prior to the present stud; (10) Endoscopic diagnosis and treatment time is more than 30 minutes; (11) Not suitable for the study, after assessment by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension;Incidence of sedative hypotension requiring treatment;Incidence of respiratory depression; | — |
Countries
china
Contacts
Public ContactYanjuan Huang
Department of Anesthesiology, the Third Affiliated Hospital of Guangxi Medical University
Outcome results
None listed