Sedative drug-related complications
Conditions
Interventions
Group 2:1:2 Volume ratio etomidate-propofol mixture
Group 3:1:3 Volume ratio etomidate-propofol mixture
Sponsors
Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-80 years; 2. The subject of sex is not limited; 3. Subjects with BMI of 18-30 kg / m2; 4. ASA I-III objects.
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative blood pressure > 160 / 100mmhg or < 80 / 60mmhg; 2. Patients with heart rate less than 50 beats / min indicated by ECG before operation; 3. Patients with acute respiratory tract inflammation within 2 weeks and without cure history; 4. Patients with severe metabolic diseases such as heart, brain, lung, liver, kidney and diabetes mellitus had previous myocardial infarction, severe myocardial ischemia and severe atrioventricular block; 5. Predict the patients who may or have had difficult airway or have a history of abnormal anesthesia recovery; 6. Patients with obvious electrolyte disorder such as hyperkalemia; 7. Patients with long-term use of immunosuppressants such as hormones or with a history of adrenocortical depression; 8. Patients who are known to be allergic to emulsions and opioids; 9. Patients who used other sedative and analgesic drugs before operation (including injection, oral administration and use of relevant Chinese patent medicines); 10. Patients suspected of abusing narcotic analgesics or sedatives; 11. Patients with neuromuscular system diseases and mental diseases who can not cooperate and cannot communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation hypotension incidence;the incidence of hypotension which need to be deal with during sedation;Incidence of hypoxemia;Incidence of apnea; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of specific adverse events;steward sobriety score;Comfort score;Score of disorientation;Awake Score;Score of satisfaction; | — |
Countries
China
Contacts
Public ContactWei Xinchuan
Sichuan Academy of Medical Sciences. Sichuan Provincial People's Hospital
Outcome results
None listed