Diabetic nephropathy
Conditions
Interventions
short course group:Take beprost sodium for 12 weeks
long course group:Take beprost sodium for 24 weeks
Sponsors
The First Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Meet the 1999 WHO diagnostic criteria for type 2 diabetes; 2) "Mogenson stage albuminuria (UMA) >30 mg / 24 h; MDRD method for estimating glomerular filtration rate (eGFR) > 60 ml·min-1· 1.73 m_2; Or chronic arterial occlusive disease caused by ulcers, intermittent claudication, pain and cold symptoms 3) Hemoglobin a1c < 7.5%; 4) Aged 18-75 years.
Exclusion criteria
Exclusion criteria: 1)Allergic to beprost sodium; 2) Subjects with severe or coagulation disorders or subjects with bloody diseases within 6 months prior to the visit or subjects unable to tolerate anti-platelet drugs are screened. 3) Systolic blood pressure >= 180mmHg and/or diastolic blood pressure >= 110mmHg at the time of interview and whose blood pressure was still higher than 170/100mmhg after two weeks of routine antihypertensive treatment. 4) Subjects with acute complications of diabetes (such as diabetic ketoacidosis and hyperosmotic state) within 3 months before the visit. 5) Suffered from major or severe diseases, such as cardiovascular and cerebrovascular events, malignant tumors, or had a history of mental illness 6) Pregnancy or lactation. 7) Urinary tract infection, urinary calculi, vaginitis or prostatitis, and the use of nephrotoxic drugs and other factors affecting urinary albumin excretion and detection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urine protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactXiaopei Cao
The First Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed