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99Tc-MDP and alendronate treatments for patients with knee osteoarthritis-multicenter clinical study

99Tc-MDP and alendronate treatments for patients with knee osteoarthritis-multicenter clinical study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000035781
Enrollment
Unknown
Registered
2020-08-16
Start date
2020-09-30
Completion date
Unknown
Last updated
2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

1:99Tc-MDP

Sponsors

Shanghai Tenth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to No maximum

Inclusion criteria

Inclusion criteria: Diagnostic criteria: Diagnostic criteria for osteoarthritis of the knee: Using the diagnostic criteria as amended by the American College of Rheumatology in 1995, which include clinical and clinical + radiological + laboratory criteria: 1. Knee pain in the last month; 2. X-ray film showed osteophyte formation; 3. Joint fluid examination was consistent with osteoarthritis; 4. Aged >=40 years; 5. Morning stiffness <=30min; 6. bone crepitus. Knee osteoarthritis is diagnosed if 1+2 or 1+3+5+6, or 1+4+5+6 are met. Inclusion criteria: Meet the above diagnostic criteria for osteoarthritis with knee pain.

Exclusion criteria

Exclusion criteria: 1. After knee replacement; 2. Inflammatory knee arthritis or joint infection; 3. Neuropathic arthropathy; 4. Reactive arthritis; 5. Periarticular fracture; 6. Gout knee arthritis; 7. Severe liver and kidney disease; 8. Traumatic arthritis; 9. Digestive diseases include gastric and esophageal delayed emptying, gastric ulcer, bleeding and esophageal reflux gastritis; 10. Obvious deformity of the knee or vascular and nerve injury of the affected limb; 11. Damaged skin around knee joint; 12. Secondary osteoporosis; 13. Long-term oral immunosuppressants, estrogen, and selective estrogen receptor modulators.

Design outcomes

Primary

MeasureTime frame
HSS;LYS;bone scan;

Countries

China

Contacts

Public ContactChao Ma

Department of Nuclear Medicine, Tenth People’s Hospital of Tongji University

ponymachao@163.com+86 18721288964

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026