liver cirrhosis
Conditions
Interventions
entecavir(non-cirrhosis):entecavi
tenofovir(non-cirrhosis):tenofovir
entecavir(cirrhosis):entecavir
tenofovir(cirrhosis) :tenofovir
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-65 years; 2. HBsAg and/or HBVDNA positive exceed 6 months; 3. matched with the critia of the CHB prevention and treatment guideline; 4. signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. HCC or AFP>100ng/ml; 2. pregrant or breasting women; 3. co-infection HAV HCV,HDV,HEV,HIV and with other chronic hepatitis; 4. with contraindication of MRI,gastroscope, liver biopsy; 5. Poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| liver stiffness;incidition of compication; | — |
Countries
China
Contacts
Public ContactChen Liang
Shanghai Public Health Clinical Center
Outcome results
None listed