Diabetic Nephropathy
Conditions
Interventions
Intervention group:subcutaneous injection of liraglutide
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged >=18 years old; 2) Type 2 diabetes diagnosed by an endocrinologist; 3) Patients from the Department of Nephrology, Shanghai Sixth People's Hospital, pathologically diagnosed as diabetic nephropathy from January 2010 to December 2020; 4) eGFR (calculated by CKD-EPI formula)> 30 ml/min/1.73m2; 5) HbA1c 6% to 9% within three months; 6) No treatment of GLP-1R or DPP-4i, SGLT2i in the past 10 weeks; 7) The stable dose of ACEI or ARB has lasted at least 4 weeks; 8) Sign the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1) Type 1 diabetes mellitus; 2) Systolic blood pressure >=180mmHg or diastolic blood pressure >=110mmHg; 3) GLP-1RA or DPP-4i use 3 months before enrollment, received insulin other than human neutral protamine (NPH) insulin or long-acting insulin analogues; 4) HbA1c >9% or HbA1c 13.9mmol/l (>250mg/dl); 5) Renal pathology confirmed DN combined with IgA nephropathy, membranous nephropathy, lupus nephritis and other pathological types; 6) Diabetic ketoacidosis occurred in the past year; 7) eGFR (calculated by CKD-EPI formula) <=30ml / min*1.73m2; 8) Maintenance dialysis or kidney transplantation; 9) Liver function insufficiency, and aspartate aminotransferase or alanine aminotransferase exceeds the upper limit of normal by more than 3 times or total bilirubin exceeds the upper limit of normal by more than 2 times; 10) Combined with other systemic diseases, and are receiving hormone or immunosuppressive therapy; 11) Patients with past or family history of medullary thyroid carcinoma (MTC) and patients with multiple endocrine tumor syndrome type 2 (MEN2); 12) Patients with severe cardiovascular disease in 8 weeks: myocardial infarction, coronary artery bypass graft or ischemic heart disease caused by PCI surgery, congestive heart failure (heart function grade ?-?, NYHA rating) 13) Patients who have had severe cerebrovascular disease within 8 weeks: stroke, significant neurological dysfunction left after stroke; 14) Patients with active gastrointestinal bleeding within three months; 15) Pregnant or lactating women and women who plan to become pregnant or have no contraceptive plan; 16) Patients with malignant tumors, or the expected survival period is less than 6 months; 17) Intolerance or allergy to liraglutide; 18) According to the judgment of the researcher, there are other diseases or conditions that reduce the possibility of enrollment or complicate enrollment, such as mental illness, frequent changes in the living and working environment, etc. that may easily cause loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urinary albumin creatinine ratio; | — |
Countries
China
Contacts
Public ContactFan Ying
Shanghai Sixth People's Hospital
Outcome results
None listed