Glaucoma
Conditions
Interventions
proteomics
Gold Standard:PACG was diagnosed based on narrow anterior chamber angles with glaucomatous optic neuropathy and corresponding VF loss. VF loss was determined by including a cluster of three or more no
Sponsors
Eye, Ear, nose and throat Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old, which met the diagnostic criteria of POAG/PACG; 2. Glaucomatous optic nerve damage with corresponding visual field defect occurred in one or both eyes; 3. Priority was given to POAG/PACG patients with severe phenotype (binocular cup/plate ratio >=0.8).
Exclusion criteria
Exclusion criteria: 1. With other inherited eye diseases or hereditary diseases; 2. other diseases that seriously impair vision and visual field, including retinitis pigmentosa, diabetic retinopathy, wet-age related macular degeneration, pathological myopia and other diseases; 3. Secondary glaucoma or secondary intraocular pressure increased diseases were excluded, including glaucoma ciliary body syndrome, pigmentation glaucoma, stripping glaucoma, neovascular glaucoma, uveitis, blunt contusion of the eye, etc.Eliminate immune system diseases; 4. with no signs of glaucoma, no other inherited eye diseases or hereditary diseases in the control samples, excluding other diseases that seriously impair vision and visual field, including retinitis pigmentosa, diabetic retinopathy, wet-age related macular degeneration, pathological myopia, etc.; 5. Secondary glaucoma or secondary intraocular pressure increased diseases were excluded, including glaucoma ciliary body syndrome, pigmentation glaucoma, stripping glaucoma, neovascular glaucoma, uveitis, blunt contusion of the eye, etc.; 6. Eliminate immune system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabonomics;proteomics; | — |
Countries
China
Contacts
Public ContactLi Shengjie
Eye, Ear, nose and throat Hospital, Fudan University
Outcome results
None listed