Crtically ill surgical disease
Conditions
Interventions
Experimental group:Optimizing nutrition therapy
Control group: Conventional nutritional therapy
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old; 2. APACHII score >=8; 3. expected to receive nutrition treatment for at least 7 days, and being able to complete written informed consent in accordance with national regulations.
Exclusion criteria
Exclusion criteria: 1. APACHII score>20; 2. life expectancy after study treatment was less than 7 days; 3. hypersensitivity to nutritional treatment ingredients; 4. serious clinical significant diseases, such as congestive heart failure or severe renal insufficiency (renal failure can uncompensated by hemofiltration or dialysis); 5. impaired liver function (total bilirubin > 3 times of the upper limit of normal value or the level of ALT >4 times of the upper limit of normal value; 6. the history of human immunodeficiency virus infection; 7. congenital abnormal amino acid metabolism; 8. serious dyslipidemia (triglyceride level > 2 times of the upper limit of normal or > 400 mg / dl or > 4.52 mmol / L) or severe hyperglycemia (blood glucose >360 mg/dl); 9. pregnant or lactating; 10. malignant tumor patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood metabonomics;Blood glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutric Score;Sarcopenia index;Serum proteins (albumin and prealbumin);Serum inflammatory markers (C-reactive protein and interleukin-6);Serum malondialdehyde;Serum insulin-like growth factor-1;Total number and classification of whole blood T cells;30-day mortality;30-day Morbility;ICU Hospital Stay;Hospital Stay; | — |
Countries
China
Contacts
Public ContactZhenyi Jia
Shanghai Sixth People's Hospital
Outcome results
None listed