Cartilage Defect of Joint
Conditions
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
Male
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Aged 16-55 years old, cartilage defect on hip, knee and ankle, male or female 2. Full-thickness large cartilage defect (3-20 cm2, International Cartilage Repair Society [ICRS] grade IV); 3. Medium or severe level pain (VAS4) with impaired joint function; 4. Be willing for surgical treatment; 5. Agree to take part into this clinical trial and signed the informed consent approved by the Ethic Committee.
Exclusion criteria
Exclusion criteria: 1. Systemic or inflammatory arthritis (e.g. rheumatoid arthritis), gout, a history of neuro-arthritis and other muscle, joint, or nervous system diseases that affect lower limb function; 2. Severe diabetes and other internal diseases which cause the patient cannot tolerate for the surgery; 3. Patient with immunosuppression or acute infection; 4. Obese, BMI>30; 5. Pregnant or Lactating women; 6. Existing cerebral disease or have a history of neurological and psychiatric disease; 7. Joint malformation or severe dysplasia; 8. Severe calcification of costal cartilage; 9. Unwillingness to comply with the protocol or procedures; 10. Other medical conditions that were not appropriate to participate in the study, including MRI contraindications (e.g. Patients with cardiac pacemaker installed).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Scores (Harris for hip,HSS for knee, AOFAS for ankle); | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;EQ-5D;Functional Scores (Harris for hip,HSS for knee, AOFAS for ankle);MOCART Scoring;Joint replacement or joint fusion;X-ray;CT scan;MRI; | — |
Countries
China
Contacts
Public ContactChangqing Zhang
Shanghai Sixth People's Hospital
Outcome results
None listed