Epilepsy
Conditions
Interventions
Patients with epilepsy group:The researchers administered transcranial magnetic stimulation (TMS) to patients with epilepsy and depressive symptoms.
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years old men and women; 2. meet the 2014 International economic Against Epilepsy (ILAE) defined Epilepsy diagnosis standard: at least 2 times interval of 24 h induced or reflective attack, or one not induced or reflective attack, but in the next 10 years recurrence risk with twice the risk of recurrence after induced seizures quite (at least 60%); Or has been diagnosed with epilepsy syndrome; 3. has not been given antidepressant medication; 4. get informed consent.
Exclusion criteria
Exclusion criteria: These patients who have a history of severe psychotic symptoms such as hallucinations and delusionsor suffer from progressive and aggravated central nervous system diseases such as acute phase of stroke, brain malignant tumor or metastatic tumor, various acute phase of encephalitis and Parkinson's diseaseor have a history of malignancy,or have severe cognitive impairment (simple Intelligence scale score <10 points),or can't take care of himself/herself.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in the latency and amplitude of event-related potentials between epilepsy patients with a HAMD-17 scale score greater than 7 and patients with a HAMD-17 scale score less than or equal to 7, and the improvement after 6 months of treatment.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploration of biomarkers of patient blood and urine: metabonomics was performed in blood and urine of patients with epilepsy and depression to explore the correlation between related polyunsaturated fatty acid metabolites and depression severity.; | — |
Countries
China
Contacts
Public ContactPeng Weifeng
Zhongshan Hospital, Fudan University
Outcome results
None listed