lung cancer
Conditions
Interventions
A:NGS detection
B:single-cell sequencing
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed inoperable advanced lung adenocarcinoma (International TMN stage 8, IIIB, IIIc, IV); 2. There are enough tissue samples for molecular detection; 3. Aged >=18 years old; 4. The score of Eastern Cooperative Oncology Group performance status (ECoG PS) was 0-2; 5. Life expectancy >=12 weeks; 6. The patients understood and voluntarily signed the written informed consent; 7. good compliance to be expected.
Exclusion criteria
Exclusion criteria: 1. The patients had uncontrollable complications, including but not limited to: symptomatic congestive heart failure, unstable angina pectoris and myocardial infarction, uncontrollable grade III hypertension, liver dysfunction, renal insufficiency, etc; 2. Patients who have received malignant tumor surgery, radiotherapy and systemic anti-tumor therapy; 3. Pregnant or nursing women; 4. Participating in any other drug research tests; 5. HIV positive patients receiving combined antiretroviral therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Molecular classification;Single cell gene expression;Overall survival;Progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| objective response rate;disease control rate; | — |
Countries
China
Contacts
Public ContactJiang Liyan
Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University
Outcome results
None listed