Post-operative Cognitive Dysfunction
Conditions
Interventions
Sponsors
Renji Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. aged 65 to 85 years; 2. To undergo elective surgery of the non-heart and non-central nervous system; 3. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Persons with mental illness; 2. Had other diseases that can lead to dementia, such as Alzheimer's disease, Lewy body dementia, prefrontal dementia, progressive supravuclear palsy, Parkinson's disease, Creutzfeldt-Jakob disease, Huntington's disease, alcohol and drug dependence, neurosyphilis, and systemic lupus erythematosus; Or preoperative MRI showed more than grade II hippocampal and temporal lobe atrophy, suggesting the possibility of Alzheimer's disease; 3. Had other brain diseases (such as stroke, multiple sclerosis, central nervous system infection with sequelae, etc.); 4. Preoperative MRI indicated the presence of diseases that impair the function of the central nervous system, such as stroke and brain tumor; 5. Unable to complete THE MMSE and MoCA scales due to other reasons (such as hearing impairment or visual impairment); 6. Patients who have MRI contraindications or cannot tolerate MRI imaging; 7. Malignant tumor stage 3 or 4 patients, and pancreatic cancer, gallbladder cancer, cholangiocarcinoma and other tumor patients with high degree of malignancy and poor prognosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of POCD;incidence of CSVD; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of delirium; | — |
Countries
China
Contacts
Public ContactPeiying Li
Department of Anesthesiology, Renji Hospital
Outcome results
None listed