Temporomandibular joint disease
Conditions
Interventions
Group 1:Autogenous graft
Group 2:alloplastic replacement group
Sponsors
Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. With lesions of combined skull base-joint-ear defect; 3. Did not participate in other clinical verification within 3 months; 4. Without acute infectious disease, mental illness, systemic disease; 5. Voluntary participate the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to titanium alloy plants, patients with acute or severe; 2. Infection or chronic infection, patients with large soft tissue defects caused by surgery; 3. Radiation osteomyelitis, acute and chronic osteomyelitis, osteoporosis; 4. Complicated with heart, lung, brain, kidney and other important organs without control; 5. Patients with mental illness; 6. Pregnant and lactating women; 7. Patients with advanced malignant tumor, distant metastasis or tumor recurrence are in critical condition, and difficult to make an accurate evaluation of the efficacy and safety of the prosthesis; 8. Patients were treated with antibiotics or chronic anti-inflammatory therapy within 4 weeks before operation; 9. Alcoholism or long-term drug abuse >= 3 times a week); 10. Uncontrollable masticatory muscle hyperfunction (night molars, clenching teeth) in patients with severe immune insufficiency leads to titanium nail overload and loosening; 11. Researchers believe that patients with poor compliance can not participate in the trial; 12. In the first 30 days before the start of surgery (day 0 of the study), patients participated in clinical trials of other drugs or devices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QOL score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain;Maximum mouth opening;Function;Maxillofacial morphology;Occlusion;Lateral movement; | — |
Countries
China
Contacts
Public ContactYang Chi
Ninth People's Hospital Affiliated to Shanghai JiaoTong University School of Medicine
Outcome results
None listed