Primary angle closure glaucoma
Conditions
Interventions
Group 1:Phacoemulsification With Goniosynechialysis
Group 2:Phacoemulsification With Trabeculectomy
Sponsors
Eye and ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 50 years; 2. Diagnosis of PACG, which is defined as: (1) posterior trabecular meshwork invisible for 180 degrees or more on gonioscopy exam with formation of primary angle synechia (PAS) and elevated IOP > 21mmhg; (2) appearance of glaucomatous optic neuropathy, defined as OCT evidence of glaucomatous damage consistent with cup-disc ratio (CDR) 0.7 or asymmetry 0.2 between eyes or a neuroretinal rim width 0.1 CDR (at 11-10 or 5-7 0' clock); (3) having glaucomatous field defect diagnosed with reliable HVF using SITA-standard 24-2 or 30-2 (Swedish Interactive Threshold Algoritm Standard) strategy, such as nasal step, arcuate defect, paracentral scotoma, altitudinal visual field loss; 3. Uncontrolled IOP with maximal tolerable medical treatment; 4. Moderate to severe stages based on Hodapp-Anderson-Parrish staging; 5. Could be clear lens or with cataract; 6. Was able to obtain Informed consent; 7. With or without prior laser iridotomy or iridoplasty.
Exclusion criteria
Exclusion criteria: 1. Previous intraocular surgery; 2. Previous eye trauma resulting in documented damage to the drainage angle (such as angle recession); 3. For patients on warfarin, International Normalized ratio (INR) > 3.0 on day of surgery; 4. Evidence of moderate non-proliferative diabetic retinopathy, neovascularization, or rubeosis iridis; 5. Chronic use of topical or systemic steroids; 6. Any condition precluding or presumed to preclude reliable visual fields, disc stereo photography, or 12 months of follow up; 7. Only eye (VA worse than 6/60 Snellen in non-study eye); 8. Patients with secondary angle closure glaucoma; 9. Pregnant or nursing women; 10. Patients with nanophthalmos.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intraocular pressure (applanation);number and types of the topical antiglaucoma drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| best corrected visual acuity;visual field;intra- and post-operative complications;corneal endothelial cell counting;thickness of the retinal nerve fibre layer;thickness of the ganglion cell complex; | — |
Countries
China
Contacts
Public ContactJunyi Chen
Eye and ENT Hospital of Fudan University
Outcome results
None listed