Perioperative hypoxemic respiratory failure
Conditions
Interventions
experimental group:iNO (5-10ppm) in addition to routine treatment
control group:routine treatment
Sponsors
Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients who received repairment surgery for AADA; 2. Patients with a persistent postoperative hypoxemia (PaO2/FiO2 = 5cmH2O, lasting for more than 2 hours); 3. No other causes of pulmonary insufficiency such as cardiogenic pulmonary edema, pneumonia, pleural effusion, segmental atelectasis, pneumothorax and pulmonary artery embolism; 4. Not being enrolled in other clinical trial of medicine; 5. Signing content and agreeing on follow-up.
Exclusion criteria
Exclusion criteria: 1. Aged < 18 years; 2. Pregnant women; 3. Mental disease; 4. Patients who developed severe complications such as: coma, cardiogenic shock, and gastrointestinal ischemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mechanical ventilation time (hours);ICU stay(days); | — |
Secondary
| Measure | Time frame |
|---|---|
| oxygenation index;postoperative acute renal injury(AKDGO criteria);hospital mortality (30 days);incidence of ventilation associated pneumonia;systematic inflammation biomarkers;acute lung injury biomarkers;pulmonary and renal function after 6-12 months postoperatively; | — |
Countries
China
Contacts
Public ContactMinYu
Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
Outcome results
None listed