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Study for the clinical effect of intracscar resection combined with intense pulsed light on keloid based on inhibiting the expression of dipeptidyl peptidase 4 in fibroblasts

Study for the clinical effect of intracscar resection combined with intense pulsed light on keloid based on inhibiting the expression of dipeptidyl peptidase 4 in fibroblasts

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000035587
Enrollment
Unknown
Registered
2020-08-14
Start date
2020-10-12
Completion date
Unknown
Last updated
2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SCAR

Interventions

Two groups:Surgery combined with intense pulsed light versus surgery

Sponsors

Shanghai First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. All cases were treated in plastic surgery department of our hospital, and they were willing to receive cicatricial excision combined with intense pulsed laser treatment for at least one year; 2. The course of keloid is more than 1 year, the diameter of the lesion is more than 1cm, and the location is not limited. The lesion is red, firm and elastic scar tissue higher than the skin surface, without local infection and ulceration, and the deep tissue is exposed. The sex, age, course of disease and lesion diameter of the control group were similar to those of the treatment group; 3. The patient had no previous hypertension, diabetes, or mental illness, and had no long-term history of hormone therapy.

Exclusion criteria

Exclusion criteria: Exclusion criteria include the previous treatment of keloids with multiple treatment methods, local ulceration of lesions, and increased recurrence after scar treatment. Below scar tissue is important vascular nerve tendon tissue, which may be exposed and difficult to heal after excision. Elderly patients can not tolerate surgical treatment, complicated with hypertension, diabetes or other cardiovascular and cerebrovascular diseases, mental disorders. Or other supervisors have no intention of surgical treatment and are not suitable for inclusion in the treatment.

Design outcomes

Primary

MeasureTime frame
Scar recurrence;

Countries

China

Contacts

Public ContactHua Shen

Shanghai First People's Hospital

samwells@sina.com+86 18917917267

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026