Type 2 Diabetes Mellitus
Conditions
Interventions
Sponsors
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: T2DM: 1. patients with T2DM who meet the diagnostic and treatment criteria of the American Diabetes Association ((American Diabetes Association,ADA) in 2019; 2. aged > = 50 years old; 3. right-handed, can cooperate with MRI examination; 4. voluntarily participate in the investigation and sign the informed consent form. Normal control group: 1. no history of diabetes; 2. aged > = 50 years; 3. right-handed, which can cooperate with MRI examination; 4. voluntarily participated in the investigation and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes, pre-diabetes, acute metabolic complications of diabetes; 2. Have a family history of dementia and are taking drugs to improve cognition (such as cholinesterase inhibitors, NMDA receptor antagonists and ginkgo biloba preparations, etc.); 3. Cannot tolerate and cooperate with MRI examination; 4. Consciousness disorder caused by hypoglycemia occurred in the past 3 years; 5. Severe mental illness, drug addiction, head injury and stroke, or other diseases that affect cognitive function; 6. Severe visual or hearing impairment; 7. Major medical diseases (such as cancer, anemia, thyroid dysfunction, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c;insulin and C-peptide;FPG;fractional anisotropy;mean diffusivity;Gray Matter Volume;Magnetic resonance image; | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline information, such as height, weight and blood pressure;blood routine;liver function;renal function; | — |
Countries
China
Contacts
Public ContactYA MIAO
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Outcome results
None listed