Anesthetic
Conditions
Interventions
Group A:3mg remimazolam
Group B:4mg Remimazolam
Group C:5mg Remimazolam
Sponsors
Department of Anesthesiology, Anhui Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are scheduled for ultrasound-guided nerve block before anesthesia; 2. Patients with ASA grade I ~ III; 3. Patients aged 18-75 years old; 4. Patients without obvious dyspnea and hypoxemia before operation; 5. Patients with educational level above primary school; 6. Patients with preoperative MMSE score >= 23; 7. Patients who sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiovascular disease ,peripheral neuropathy, central nervous system disease, puncture site infection,coagulation disorder; 2. Patients with mental disorders; 3. BMI >= 35kg/m2 4. Pregnant women; 5. Lactating women; 6. Failure to follow up, drop out of the study due to personal factors, and 7. Patients who are allergic to drugs in this study; 8. History of taking benzodiazepines and other sedative drugs and opioids abuse; 9. Patients with communication disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic index;Spo2;modified observer's assessment of alert /sedation;Depth of anesthesia, Nacrotrend; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypoxemia;Incidence of injection pain;onset time;awakening time; | — |
Countries
China
Contacts
Public ContactXiao Yimin
Anhui Provincial Cancer Hospital
Outcome results
None listed