Degenerative diseases and injuries of the spine
Conditions
Interventions
Group 1:Gabapentin combined with Celebrex
Group 2:Pregabalin and Celebrex
Group 3:Gabapentin combined with Parecoxib
Group 4:Pregabalin combined with Parecoxib
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-85 years; 2. Single segment fusion and internal fixation: lumbar disc herniation, lumbar spinal stenosis, lumbar spondylolisthesis; 3. Two level fusion and internal fixation: lumbar disc herniation, lumbar spinal stenosis, lumbar spondylolisthesis; 4. Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to amide local anesthetics or sulfonamides; 2. Patients with severe liver and kidney dysfunction, bronchospasm, asthma, active peptic ulcer and bleeding, severe heart failure, creatinine clearance rate < 60ml / min and creatinine greater than 110; 3. Pregnant women or objects in lactation period; 4. Patients with acute pancreatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS scores;PCA dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to ambulation;hospital stay;adverse events; | — |
Countries
China
Contacts
Public ContactZhengxue Quan
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed