Neonatal Respiratory Distress Syndrome
Conditions
Interventions
Control Group:Non-invasive Mechanical Ventilation (NIPPV or NCPAP)
Experimental Group:Nebulised Surfactant Combined With Non-invasive Mechanical Ventilation (NIPPV or NCPAP)
Sponsors
Guangdong Women and Children Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Fetal age <= 28 weeks and birth weight <= 1000g; 2. Aged <= 6 hours after birth; 3. Those who meet the RDS Diagnostic Standards for Practical Neonatology (4th edition); 4. With the infant's guardian's informed consent.
Exclusion criteria
Exclusion criteria: 1. Preterm infants need invasive mechanical ventilation when admitted in NICU; 2. Congenital malformations of the respiratory system, complex congenital heart disease, severe intrauterine infection, severe instability of the circulatory system, congenital genetic metabolic diseases and chromosomal diseases; 3. Those who fail to complete the study and cannot provide complete data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of neonates with respiratory failure of each group ;The incidence of bronchopulmonary (BPD) in each group ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of mechanical ventilation;The duration of oxygen therapy ;Blood gas;Vital signs;Ventilator parameters;The incidence of complications (necrotizing enterocolitis, intracranial hemorrhage, cholestasis, retinopathy of prematurity, extrauterine growth retardation, pneumothorax/air leak);The incidence of death; | — |
Countries
China
Contacts
Public ContactLiu Ying
Guangdong Women and Children Hospital
Outcome results
None listed