coronary artery disease
Conditions
Interventions
open chest group:open chest coronary artery bypass grafting
minimally invasive group:minimally invasive coronary artery bypass grafting
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male patients aged between 40 and 80 years old or non-lactation and non-pregnant women with good compliance; 2. Meet the diagnostic criteria of coronary heart disease and have indications of coronary artery bypass surgery; 3. Echocardiography indicated normal or nearly normal left ventricular systolic function (ejection fraction EF > 40%); 4. Preoperative electrocardiogram showed no frequent ventricular premature beats or other serious malignant arrhythmias; 5. Patients with normal cognitive ability, willing to participate in the trial and able to complete clinical follow-up; Voluntary signing of informed consent forms approved by the ethics committee.
Exclusion criteria
Exclusion criteria: 1. Patients with clear diagnosis of coronary heart disease but unsuitable for coronary artery bypass transplantation due to various reasons; 2. Emergency surgery (with IABP or ECMO) or re-cardiac surgery; 3. Combined with other heart diseases requiring surgical treatment at the same time, such as valvular diseases or ascending aortic lesions; 4. Patients with systemic active infection; 5. Severe liver dysfunction (GOT or GPT >); 6. Severe renal insufficiency (serum creatinine (Cr) >200umol/L, oliguria/anuria, receiving dialysis treatment); 7. Patients with severe respiratory dysfunction (FEV1 < 70%); 8. Carriers of infectious diseases such as hepatitis b, c or HIV; 9. Patients with obvious bleeding tendency and hematological diseases; 10. Patients with malignant tumors and end-stage diseases; 11. The patient's life expectancy is less than 6 months; 12. Alcohol and drug abusers within the last 3 months; 13. Patients with serious cerebrovascular diseases (patients with cerebral infarction or cerebral hemorrhage or severe sequelae at present or within six months).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse cardiovascular and cerebrovascular events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events after surgery in early period(<30?); | — |
Countries
China
Contacts
Public ContactWang Rong
Chinese PLA General Hospital
Outcome results
None listed