schizophrenia
Conditions
Interventions
rTMS group:rTMS+MECT
sham rTMS group:sham rTMS+MECT
Sponsors
Tongji Hospital of Tongji University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 65 years old, be able to cooperate with rTMS and MECT treatment; 2) Obtain the written informed consent of the subjects and family members/legal guardians; 3) Meet the diagnostic criteria for schizophrenia or schizophrenia in the American Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV) and the supporting SCID clinical examination, 4) Inpatients in the acute phase (ie, patients with first-onset schizophrenia and patients with recurrence of acute exacerbation of psychotic symptoms), of which the total course of relapse patients should be less than 5 years, and meet the following restrictions at the same time; 5) PANSS scale rough score >=70 points 6) In the following PANSS items, there are 2 or more items >=4 points (P1. Fantasy, P2. Association loose, P3. Hallucinations, P4. Excitement, P6. Suspicion/victimization, P7. Hostility, G4. Body tension, G8. No cooperation, G9. Unusual thinking content, G14. Impulse control disorder); 7) Maintain a stable dose of antipsychotics during rTMS treatment (the drugs are limited to atypical antipsychotics, and the dosage is equivalent to olanzapine 10-20mg/d); 8) Not currently receiving clozapine treatment or not receiving sufficient and sufficient course of clozapine treatment in the previous course.
Exclusion criteria
Exclusion criteria: 1) There are contraindications to rTMS, MECT or MRI: metal foreign bodies in the skull, persons with pacemakers, persons with cochlear implants, intracranial hypertension; 2) Mental retardation and nervous system diseases, major physical diseases; 3) History of brain trauma, MRI examination showed abnormal brain structure; 4) History of alcohol or drug abuse and dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PANSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| MCCB;GAF;MRI;MEG; | — |
Countries
China
Contacts
Public ContactLu Zheng
Tongji Hospital of Tongji University
Outcome results
None listed