Alzheimer's disease
Conditions
Interventions
Gold Standard:1. MMSE scale
2. Head MRI
3.A beta 1-40, A beta 1-42
4. Standard uptake value (SUV)
5. Distribution volume ratio (DVR)
6. Binding potential(BPND).
Index test:beta-amyloid 
Sponsors
Xinhua Hospital Affliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. A patient with Alzheimer's disease; a patient who is clinically diagnosed as Alzheimer's disease and preclinical Alzheimer's disease; 2. Healthy subjects: healthy people who exclude diseases such as other neurological diseases; 3. The hematopoietic function of bone marrow and the function of liver and kidney were normal; 3.1 White blood cell count > 3000/uL, neutrophil count >=1500/uL, platelet >=1000000/uL, hemoglobin >=9 g/dL. 3.2Serum creatinine =60mL/min; 3.3 Blood bilirubin < 1.25 times normal upper limit, glutamic pyruvic transaminase and glutamic oxaloacetic transaminase < 2.5 times normal upper limit; 4. Be able to follow the research plan and follow up on a regular basis; 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for patients with Alzheimer's disease (supplementary blood tests and auxiliary tests such as brain MRI to rule out other causes of cognitive impairment or dementia or concomitant diseases such as vascular damage). Other diseases sufficient to cause related symptoms: (1) depression; (2) cerebrovascular disease; (3) poisoning, inflammation or metabolic disorder. 2. Exclusion criteria for healthy subjects: healthy people with neurological diseases and tumors / hypertension / diabetes were excluded; 3. abnormal blood routine and abnormal liver and kidney function; 4. Concomitant diseases are not suitable for radiopharmaceutical treatment; 5. Other conditions (religion, psychology, etc.) affect informed consent, compliance with research programs or failure to follow up on time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE scale;A beta 1-40, A beta 1-42;Standard uptake value;Distribution volume ratio;Binding potential;Head MRI; | — |
Countries
China
Contacts
Public ContactWang Hui
Xinhua Hospital Affliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed