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Methylation analysis of circulating tumor DNA in gastric cancer

Methylation analysis of circulating tumor DNA panel as marker of early diagnosis and prognostic evaluation in gastric cancer: a single-center, prospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000035454
Enrollment
Unknown
Registered
2020-08-11
Start date
2020-10-01
Completion date
Unknown
Last updated
2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric cancer

Interventions

Gold Standard:Clinical outcome
Index test:endoscopy

Sponsors

Zhongshan Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. The subject is scheduled to undergo an endoscopy because of medical indications; 2. The subject must have personally signed and dated the patient informed consent form indicating that he/she has been informed of all pertinent aspects of the study; 3. The subject must be willing and able to comply with all study procedures.

Exclusion criteria

Exclusion criteria: 1. The subject who is unable to undergo gastroscopy; 2. The subject with previous total or partial gastrectomy; 3. The subject has other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may interfere with the interpretation of study results and in the judgment of the investigator would make the subject unsuitable for entry into the study (e.g.,Having serious comorbidities: cancer, severe renal or hepatic insufficiency, severe cardiac or respiratory failure); 4. The subject is unwilling or unable to provide signed informed consent; 5. The subject who is pregnant.

Design outcomes

Primary

MeasureTime frame
ctDNA methylation;

Secondary

MeasureTime frame
CpG methylation haplotypes block;

Countries

China

Contacts

Public ContactLing Dong

Zhongshan Hospital of Fudan University

dong.ling@zs-hospital.sh.cn+86 13916877798

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026