periodontal disease
Conditions
Interventions
control group: amoxicillin and metronidazole
Sponsors
School and hospital of Stomatology, Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Male or female, aged 18-65 years, in good health; willing and able to sign informed consent; clinically diagnosed as periodontitis, the study tooth has periodontal vertical bone defect, with baseline PD >=7mm. After operative debridement, it is a vertical bone defect located adjacent to the tooth, and the depth of the vertical bone defect is >=4mm, there is at least one bone wall, with keratinized gingiva of >=2mm width, and X-ray shows that the base of bone defect is at least 3 mm in the crown of the root apex; the teeth will be cleaned and scraped within 2 months before joining the group; the tooth mobility is less than or equal to I degree; and there is no root furcation disease.
Exclusion criteria
Exclusion criteria: Patients with systemic disease history; patients allergic to azithromycin, amoxicillin or metronidazole; study tooth with periodontal surgery history; patients with acute infection at the surgical site; patients with smoking; patients who are participating in other clinical trials; subjects who object to the use of pig derived materials due to religious reasons; subjects with poor predicted compliance or with other factors that not suitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical attachment level (CAL);probing depth (PD);Bone filling percentage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gingival retraction; | — |
Countries
China
Contacts
Public ContactXiangzhen Yan
School and hospital of Stomatology, Tongji University
Outcome results
None listed