oropharyngeal cancer
Conditions
Interventions
control group:Extended excision of oropharyngeal cancer with temporary disconnection of the mandible
experimental group:Extended excision of oropharyngeal with Da Vinci robot through mouth
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 80 years; 2. No restrictions on men or women; 3. Preoperative pathology indicated squamous cell carcinoma; 4. The primary site is the oropharynx (including tonsils, soft palate, base of tongue and side wall of pharynx); 5. Preoperative enhanced CT/MRI of maxillofacial region, chest CT or neck ultrasound were performed. The oral and oropharyngeal cancer must be staged in T1-2, N0, M0, according to the 8th edition of the AJCC; 6. Within 1 week before grouping, blood routine, coagulation function, liver function, renal function and ECG were normal (hemoglobin>80 g/L; absolute neutrophil count > 1.5 x 10^9/L, platelet > 100 x 10^9/L; bile red = 50 ml/min) 7. Functional oral feeding grades were performed one week before surgery, and those with grades 5-7 will be included in the trial.
Exclusion criteria
Exclusion criteria: 1. Complicated with other malignant tumor or recurrence of or primary tumor within 5 years; 2. History of severe drug allergy; 3. Patients with pregnancy, lactation or neurological disorders; 4. Patients who have participated in other clinical trials; 5. Patients who have received radiotherapy, chemotherapy and targeted drugs and other anti-tumor treatments before surgery; 6. Mouth opening < 3.5cm; 7. Contraindications associated with general anesthesia surgery (such as hypertension, diabetes etc, which are difficult to control with drugs); 8. Patients with congenital immune deficiency or organ transplantation; 9. Patients with diseases related to HBV, HCV, HIV, TRUST, etc..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of wound healing;Postoperative complications;Swallowing quality of life questionnaire;Video fluoroscopic swallowing study;Primary lesion and neck condition; | — |
Countries
China
Contacts
Public ContactChenping Zhang
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed