Acute lacunar infarction
Conditions
Interventions
experimental group:Conventional treatment + anisodine hydrobromide
control group:Conventional treatment
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years and above, sex is not limited; 2. Lacunar infarction was diagnosed by CT or magnetic resonance imaging (MRI), with or without white matter lesions; 3. Patients with acute lumen infarction were conscious, but with mild cognitive impairment; 4. NIHSS score was 3-15; 5. Understand and sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Severe disturbance of consciousness (NIHSS score IA >= 2); 2. Lacunar infarction caused by large artery infarction; 3. Brain imaging examination confirmed that there were diseases leading to similar symptoms, such as brain tumor, encephalitis, brain abscess, etc., or hemorrhagic cerebral infarction, epidural hematoma, etc; 4. Patients with serious heart disease, serious arrhythmia and heart failure; 5. Patients with severe abnormal liver and kidney function (ALT > 2uln, renal function laboratory index CR > 1.5uln); 6. Patients with a history of mental illness or dementia; 7. Significant drug or alcohol abuse; 8. Allergic constitution, and allergy to two or more drugs or foods; or known to be allergic to ingredients of the drug; 9. Pregnant, planned or lactating women; 10. Participated in other clinical trials in the past 3 months; 11. Patients who were not suitable for the study were determined by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of neural function and cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of ADL and Fazekas scores;Incidence of combined vascular events (including stroke, myocardial infarction, vascular death and angina pectoris) at 90 days after onset;Recurrence of lacunar infarction on day 90 and 180;Mortality rate; | — |
Countries
China
Contacts
Public ContactZhang Xiangjian
The Second Hospital of Hebei Medical University
Outcome results
None listed