Glioma
Conditions
Interventions
trial group:PMSA+GD2 CAR T
Sponsors
Guangdong Clifford Hospital
Eligibility
Sex/Gender
All
Age
8 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Grade IV glioma, with residual lesions or progression after surgery or radiotherapy, CT or MRI reveals that the maximum diameter of the residual tumor is >= 1cm; 2) Aged >=8 and = 80%; 6) ECOG =12 weeks; 8) Absolute lymphocyte value >= 0.8*10^9/L, ANC >= 0.75*10^9/L, PLT >= 75*10^9/L; 9) AST and AST do not exceed 5 times the upper limit of the normal value; 10) Bilirubin does not exceed 3 times the upper limit of normal; 11) Serum creatinine does not exceed 2 times the upper limit of normal; 12) The patient or family member signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1) The disease progresses rapidly; 2) Receiving treatment with other new drugs and still in the care period; 3) Those who use immunosuppressive agents (including hormones); 4) History of severe heart and lung disease; 5) Actively infected persons (including viral and bacterial infections); 6) Those who suffer from other uncontrolled diseases that the researcher thinks are not suitable for joining; 7) CNS neuroblastoma patients with central nervous system involvement; 8) Any situation that the researcher believes may increase the risk of the subject or interfere with the test results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor size;PR, CR, SD, PD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioral Observation and Evaluation;Tumor markers;Survival time (survival rate);progression free time;Quality of life assessment;Toxic reaction (adverse reaction); | — |
Countries
China
Contacts
Public ContactCai Qichun
Guangdong Clifford Hospital
Outcome results
None listed