primary ovarian insufficiency
Conditions
Interventions
The control group:estrogen-progesterone replacement
Experimental group 1:nicotinamide
Experimental group 2:estrogen-progesterone replacement combined with nicotinamide
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Under 40 years of age; 2. Have established regular menstrual cycle, oligomenorrhea / amenorrhea >=4 months; 3. FSH (Follicle-Stimulating Hormone) > 25 IU/mL; 4. Subclinical stage of POI, FSH level is 15-25U/L.
Exclusion criteria
Exclusion criteria: 1. Secondary ovarian insufficiency (e.g.hypothalamic cause); 2. Abnormal karyotyping (e.g. turner syndrome, fragile X syndrome); 3. History of previous malignant or ovarian tumors, history of ovarian therapy; 4. Polycystic ovarian syndrome; 5. Congenital uterine anomalies; 6. Severe endometriosis; 7. Autoimmune disease, history of severe familial genetic disease, etc; 8. HIV+, hepatitis B, C; 9. History of serious drug allergy or allergic constitution; 10. Acute or chronic infection, hematologic disease, angiocardiopathy, pulmonary disease, liver disease, nephropathy, pancreas disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follicle-stimulating hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate;Anti-Mullerian Hormone (AMH) serum level;Number of Antral follicle development;Estradiol (E2) serum level;Ovarian volume;Luteinizing hormone; | — |
Countries
China
Contacts
Public ContactShaohua Xu
Shanghai First Maternity and Infant Hospital
Outcome results
None listed