A prospective, randomized, controlled trial for the efficacy and safety of improving left ventricular remodeling in combined use of sacubitril-valsartan and dapagliflozin compared to RAAS inhibitors in very elderly patients with acute myocardial infarction at the early stage of hospitalization

A prospective, randomized, controlled for the efficacy and safety of improving left ventricular remodeling in combined use of sacubitril-valsartan and dapagliflozin compared to RAAS inhibitors in very elderly patients with acute myocardial infarction at the early stage of hospitalization

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000035387

Enrollment

Unknown

Registered

2020-08-09

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute myocardial infarction

Interventions

Group A:sacubitril-valsartan and dapagliflozin

Group B:RAAS inhibitors

Eligibility

Sex/Gender

All

Age

75 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosed as acute myocardial infarction by ECG, myocardial enzymes and one of imaging evidence such as echocardialgraphy, CCTA, DSPECT, cardiac MRI and angiography according to the 2018 World Health Organization (WHO) classification of AMI; 2. Aged >= 75 years.

Exclusion criteria

Exclusion criteria: 1. Severe renal insufficiency (EGFR < 30ml / min / 1.73m2); 2. Patients with hypotension (SBP <=100mmhg or DBP <=60mmhg); 3. According to the judgment of the researcher, the subjects were not credible or had poor compliance.

Design outcomes

Primary

Measure	Time frame
Left ventricular end diastolic diameter;Left ventricular end systolic diameter;GLSS;	—

Secondary

Measure	Time frame
biochemical criteria;quality of life asessment;mortality;BNP;	—

Countries

China

Contacts

Public ContactShi Kailei

Huadong Hospital

1879542@qq.com+86 18121228705

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026