Infection
Conditions
Interventions
the loading group:the first vancomycin dose was 1.5 times of the conventional dose
control group:The first dose of vancomycin was given a regular dose
Sponsors
Department of critical care medicine, Ruijin hospital north affiliated to Shanghai jiaotong university school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Treated in the department of critical care medicine, Ruijin hospital north affiliated to Shanghai jiaotong university school of medicine between June 2018 and June 2020; 2. Patients who were suspected or confirmed gram-positive bacterial infection and were treated with vancomycin; 3. Patients who measured the serum concentration of vancomycin before the second dose and the fifth dose; 4. Aged > 18 years.
Exclusion criteria
Exclusion criteria: 1. Patients on renal replacement therapy during the treatment; 2. Treatment duration of vancomycin <3days; 3. Missing data such as vancomycin concentrations, follow-up data; 4. Vancomycin was administered within 3 days before admission to the ICU; 5. Changed the infusion to1continuous infusion of vancomycin before fifth dose; 6. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentration of vancomycin; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine; | — |
Countries
China
Contacts
Public ContactHuang Yanxia
Department of critical care medicine, Ruijin hospital north affiliated to Shanghai jiaotong university school of medicine
Outcome results
None listed