knee joint cartilage injury
Conditions
Interventions
Autogenous bone marrow concentrate treatment group:Intra articular injection of autogenous bone marrow concentrate
Subchondral bone drilling treatment group:Treatment of micro fracture of subchondral bone drilling,The diameter of the pore was 1.0-1.2mm
Sponsors
920th Hospital of the Joint Service Support Force
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 55 years old; (2) Acute or chronic knee cartilage injury caused by trauma or osteochondritis exfoliation, with an area of 2.0-10cm2; (3) Before the study, the subjects were willing and able to sign the informed consent approved by the ethics committee; (4) Willing to work closely with doctors to develop strict postoperative rehabilitation procedures; (5) The patient is willing to cooperate with the whole treatment process, and is willing to bear the corresponding consequences or related consequences after the treatment process; Complications, and the corresponding postoperative management measures; (6) According to the judgment of the researcher, the subject can understand the clinical study and cooperate to complete the whole study process; (7) The subjects were able to read, express and understand the contents of the study plan, and provide feedback in appropriate language.
Exclusion criteria
Exclusion criteria: (1) Written consent for voluntary participation in clinical research cannot be provided; (2) The patients were obese, BMI index >=30kg/m2; (3) X-leg or O-leg; (4) Known history of immune system disease, and causes joint and meniscus damage; (5) For arthritis with Kellgren & Lawrence grade III and above, the meniscus is damaged in a large area; (6) There are serious heart, liver, kidney and lung dysfunction; (7) Pregnant women and lactating women; (8) Known HIV infected or drug addicts; (9) Bacterial infection or suppurative arthritis of the knee joint cavity; (10) Patients with serious primary or mental diseases such as tissue metabolism disorder, immune function disorder, hematopoietic system, endocrine system, etc., such as coagulation dysfunction, serious diabetes, drug abuse and so on; (11) Patients with poor compliance, such as unwillingness or inability to limit activity, follow doctor's orders, and fail to follow up on time; (12) Participate in another clinical study within 6 months; (13) Patients with diseases that the researchers think may affect their participation in this study, such as mental disorders, alcohol or drug addiction, malignant or severe Illness, etc. (14) The subjects were accompanied by serious nervous system or musculoskeletal system diseases, such as myasthenia gravis, muscular dystrophy, cerebral infarction, cerebral palsy, etc. (15) The subjects could not express, read, express and understand the contents of the research plan, and could not provide feedback in appropriate language; (16) The subjects had other diseases and their life expectancy was less than 2 years; (17) Subjects were participating in other clinical trials and did not reach the end point; (18) Other patients who were not suitable for the study were considered by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| symptom; | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI results;Knee function score; | — |
Countries
China
Contacts
Public ContactXu Yong-qing
920th Hospital of the Joint Service Support Force
Outcome results
None listed